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Treatment of Painful Diabetic Neuropathy with Topical Capsaicin A Double-Blind, Vehicle-Controlled Study, The Capsaicin Study Group, Arch Int Med 151:2225-222991., , 1991 See this aricle in Pubmed Article Abstract A multicenter study was conducted to establish the efficacy of topical 0. 075%capsaicin cream in relieving the pain associated with diabetic neuropathy.Capsaicin or vehicle cream was applied to painful areas four times per day for 8 weeks in patients randomly assigned to one of two groups.Pain intensity and relief were recorded at 2-week intervals using physician's global evaluation and visual analog scales.Analysis at final visit for 252 patients showed statistical significance favoring capsaicin compared with vehicle for the following:69.5%vs 53.4%pain improvement by the physician's global evaluation scale,38.1%vs 27.4%decrease in pain intensity,and 58.4%vs 45.3%improvement in pain relief.With the exception of transient burning,sneezing,and coughing,capsaicin was well tolerated. Study results suggest that topical cansaicin cream is safe and effective in treating painful diabetic neuropathy.

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